AN UNBIASED VIEW OF SOK

The purpose of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which plays an essential regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also